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Health Line

DIABETICS have an elevated risk of developing heart disease, and now researchers believe they have found one reason why.

It appears that a class of proteins that are responsible for clearing fat from the blood may not work as well in the presence, of high blood sugar levels seen in uncontrolled diabetes, according to Dr. Neil S. Shachter. Assistant Professor of Medicine at Columbia University College of Physicians and Surgeons in New York.

"Clearance is the problem," said Shachter, who conducted a study in mice looking at the problem. This excess fat may build up in the arteries of diabetics, making them more prone to atherosclerotic heart disease and a number of other complications of diabetes, he explained. Shachter and colleagues noted that after diabetics eat a meal, the fat in their blood tends to remain elevated longer than it does in people without diabetes.

The researchers found that a class of proteins found in the liver known as heparan sulphate proteoglycans (HSPGs), which are responsible for transporting fats, did not work as well as usual in the highsugar environment. HSPGs are comprised of protein and sugar chains, and it appears that in the diabetic, not as many HSPGs are created so less fit is being cleared.

As reported in Business Line News Service
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